Spitz Nevi With Novel BRAF Fusions: A Report of Two Cases With Striking Morphologic Features

American Journal of Dermatopathology 2026

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Authors: Zachary Corey, Danica D. Wiredja, Nicholas Willard, Joshua A. Wisell, Shyam S. Raghavan
DOI: 10.1097/dad.0000000000003222
Cited by: 0
References: 13

Abstract

ABSTRACT: Spitz neoplasms comprise a spectrum of melanocytic lesions with overlapping clinical and histologic features. BRAF fusions account for only 5%-6% of Spitz neoplasms with a limited number of fusion partners being characterized. We report 2 Spitz nevi with novel BRAF fusions and reproducible morphologic findings. The first case, a 35-year-old man with a finger mass, morphologically demonstrated intraepidermal and dermal proliferation of enlarged epithelioid melanocytes without maturation, and a striking pattern of neurotropism and angiotropism. Immunohistochemistry revealed

Fields of Study & Subjects

Cutaneous Melanoma Detection and Management Melanoma and MAPK Pathways Neurofibromatosis and Schwannoma Cases

Publication details

Journal / source
American Journal of Dermatopathology
Volume
48
Issue
5
Pages
397–401
Publication date
4 March 2026
Language
EN