Regenerative Aesthetics: Present Advances and Emerging Strategies for Optimized Tissue Health

BACKGROUND: The field of regenerative aesthetics is advancing rapidly, shifting from traditional cosmetic techniques to therapies targeting the biological mechanisms behind tissue degeneration. OBJECTIVE: The authors aimed to explore emerging therapies within the 3 pillars of regenerative aesthetics, cellular treatments, biochemical cues, and scaffolds highlighting recent advancements, regulatory challenges, and opportunities for further research. METHODS: A literature review was performed to identify clinical evidence for regenerative modalities in aesthetic practice, with 74 articles included for evaluation. RESULTS: The review covers adipocyte- and umbilical cord-derived stem cells and stromal vascular fraction (SVF) in aesthetic treatments. Nanofat, created through mechanical emulsification, shows promise by providing higher SVF yields while circumventing stricter regulations on enzymatic methods. Exosomes demonstrate therapeutic potential in wound healing, pigmentation disorders, and skin rejuvenation. Polydeoxyribonucleotides and polynucleotides exhibit significant tissue repair and anti-inflammatory effects; polynucleotides also serve as scaffolds for tissue volumization. In addition, new data suggest that poly- l -lactic acid promotes volumizing effects by increasing adipose-derived stem cells and remodeling the extracellular matrix. CONCLUSION: Further research and regulatory standardization are needed. Future directions may involve integrating regenerative aesthetics with longevity medicine to enhance both rejuvenation and sustained tissue function over time.