Associations of Glycemic Control and Diabetes Duration With Dupuytren Disease in Men and Women With Type 1 and 2 Diabetes

Background: Dupuytren disease (DD) is a benign fibroproliferative disorder affecting the hand. Although diabetes mellitus is a known risk factor, the underlying mechanisms behind this association remain unclear. This study aimed to examine the relationship between glycemic control and DD in type 1 (T1D) and type 2 diabetes (T2D), and to identify other metabolic risk factors influencing DD risk. Methods: In this retrospective registry study, data from the Swedish National Diabetes Register and the Skåne Healthcare Register were cross-linked. In total, 96,039 individuals aged 18 years or older with T1D or T2D were included. Sex-stratified, multivariable logistic regression models calculated associations between HbA1c levels and DD risk. Interaction analyses evaluated whether diabetes duration modified the association between HbA1c levels and DD risk. Results: Longer diabetes duration consistently increased the risk of DD in both T1D and T2D groups. A trend toward increased DD risk with higher HbA1c levels was seen in T1D ( P > 0.05). Higher body mass index was inversely associated with DD in men and women with T2D ( P < 0.05). No interaction was observed between HbA1c levels and diabetes duration. Conclusions: Diabetes duration seems to be a strong and independent risk factor for DD in T1D and T2D. Although a trend toward higher DD risk with elevated HbA1c was observed in T1D, no interaction with diabetes duration was found. A higher body mass index was associated with a lower risk of DD in individuals with T2D.