A Novel Voxel-based Technique for 3-Dimensional Transparent Visualization of Lip–Nasal Vasculature

Conventional imaging cannot capture the spatial relationship between soft tissue and vasculature in patients with cleft lip. Here, a novel technique integrating micro-computed tomography imaging with voxel-based 3-dimensional reconstruction was developed using the Bioxel Nodes plugin in Blender. High-resolution modeling of both vasculature and surrounding soft tissue with adjustable transparency was achieved by segmenting computed tomography data based on intensity thresholds. This method allows intuitive visualization of the superior labial artery, columellar branches, and lateral nasal arteries. Notably, a spatial correlation was observed between these vessels and embryonic fusion zones of facial prominences, suggesting a potential link to cleft lip pathogenesis. Compared with traditional modeling methods, the current workflow offers improved anatomical clarity, enhanced interactivity, and lower technical barriers. In this study, Blender-based voxel rendering was applied for simultaneous reconstruction of blood vessels and transparent soft tissue in the perioral and perinasal region. This technique may assist in flap design, injection planning, and intraoperative vascular preservation, and thus provides a valuable tool for craniofacial surgery and education.