Liver transplantation for propionic acidemia: Survival and metabolic outcomes

Hepatology Communications 2026 Open access

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Authors: Xiaochen Bo, Yiqing Zhang, Jiahao Ge, Siyuan Tang, Xinye Zhu, Mei Long, Jie Xi Li, Qiang Xia, Taihua Yang, Ping Wan
DOI: 10.1097/hc9.0000000000000867
Cited by: 2
References: 37

Abstract

BACKGROUND: Propionic acidemia (PA) is a severe metabolic disorder that leads to multiorgan damage despite comprehensive management. Liver transplantation (LT), particularly living donor liver transplantation, has been proposed as an effective treatment, but evidence from large-scale studies is limited. METHODS: This retrospective study analyzed clinical outcomes of 39 children with PA who underwent LT at Shanghai Ren Ji Hospital between September 2017 and October 2023. The data included demographics, surgical details, biochemical/metabolic markers, and progression of symptoms. Patients were grouped based on the Diagnosis-to-Transplant Interval (

Fields of Study & Subjects

Metabolism and Genetic Disorders Liver Disease and Transplantation Renal function and acid-base balance

Publication details

Journal / source
Hepatology Communications
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
10
Issue
2
Publication date
9 January 2026
Language
EN