Liver transplantation is the major determinant of ≥10-year survival in patients with hepatocellular carcinoma

Hepatology Communications 2026 Open access

Read full text
Authors: Mohammad Saeid Rezaee Zavareh, Joseph C. Ahn, Hyunseok Kim, Michael Luu, Walid Ayoub, Alexander Kuo, Hirsh D. Trivedi, Yun Wang, Aarshi Vipani, Tsuyoshi Todo, Georgios Voidonikolas, Justin A. Steggerda
+9 more Steven A. Wisel, Todd V. Brennan, Cristina Ferrone, Irene K. Kim, Kambiz Kosari, Nicholas Nissen, Neehar D. Parikh, Amit G. Singal, Ju Dong. Yang
DOI: 10.1097/hc9.0000000000000951
Cited by: 1
References: 37

Abstract

BACKGROUND: Hepatocellular carcinoma (HCC) has a poor long-term prognosis due to high recurrence and cirrhosis-related mortality, even after potentially curative treatments such as liver transplantation (LT), surgical resection, or ablation. This study aimed to identify factors associated with ≥10-year survival in HCC patients. METHODS: A retrospective cohort study was conducted among HCC patients diagnosed between 2004 and 2022 using the National Cancer Database. Multivariable Cox regression was used to identify predictors of overall survival, and logistic regression was used to identify predictors of ≥10-year survival. RESULTS: Among 249,600 HCC patients, 177,585 (71.2%) died within 5 years, 8613 (3.5%) died at 5-10 years, 54,988 (22.0%) were alive with

Fields of Study & Subjects

Hepatocellular Carcinoma Treatment and Prognosis Cholangiocarcinoma and Gallbladder Cancer Studies Cancer Mechanisms and Therapy

Publication details

Journal / source
Hepatology Communications
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
10
Issue
5
Publication date
24 April 2026
Language
EN