Choroidal Structural and Vascular Changes in Early Primary Angle Closure Glaucoma

PRÉCIS: Thicker CT and higher CVI in the 1-12 mm circumferential annular area were noted in early PACG patients compared with healthy controls. More importantly, CVI may serve as a more sensitive indicator for disease progression. PURPOSE: To investigate changes of choroidal thickness (CT) and choroidal vascularity index (CVI) in eyes with early primary angle closure glaucoma (PACG) based on swept source optical coherence tomography angiography (SS-OCTA). METHODS: A total of 86 early PACG patients (86 eyes) and 79 healthy individuals (79 eyes) were enrolled. All subjects underwent 12×12 mm macular scan and 6×6 mm optic disc scan to analyze and compare CT and CVI. Univariate and multivariate linear regression analyses were used to evaluate the relevance of CT and CVI to related factors. RESULTS: In all macular regions, patients with early PACG exhibited thicker CT and higher CVI as compared with healthy controls (all P