Linezolid Toxicity in South African Children With Rifampicin-resistant Tuberculosis

The Pediatric Infectious Disease Journal 2026

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Authors: Sacha Horn, Louvina E. van der Laan, Hendrik Simon Schaaf, A. C. Hesseling, Anthony J. Garcia-Prats
DOI: 10.1097/inf.0000000000005135
Cited by: 0
References: 9

Abstract

There is little evidence about linezolid-attributed toxicity in children with drug-resistant tuberculosis. In a prospective cohort of South African children treated with linezolid, anemia, thrombocytopenia and peripheral neuropathy were common, sometimes severe, and often required active management. Peripheral neuropathy and grade 3/4 events typically occurred after ≥3 months of treatment.

Fields of Study & Subjects

Antimicrobial Resistance in Staphylococcus Tuberculosis Research and Epidemiology Antibiotics Pharmacokinetics and Efficacy

Publication details

Journal / source
The Pediatric Infectious Disease Journal
Volume
45
Issue
6
Pages
495–497
Publication date
5 January 2026
Language
EN