Epidemiology of Bloody Diarrhea, Shiga Toxin–producing Escherichia coli and Hemolytic Uremic Syndrome in Children

The Pediatric Infectious Disease Journal 2026

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Authors: Giacomo Tamburini, Laura Daprai, Alessandra Gazzola, Daniele Rossetti, Elena Tomassini, Giulia Dilio, Thomas Ria, Letizia Dato, Maria Cristina Mancuso, Mario Vittorio Luini, Francesca Tel, Ilaria Possenti
+4 more Chiara Francesca Magistrali, Anna Paola Callegaro, Gianluigi Ardissino, on behalf of the ItalKid-HUS Network
DOI: 10.1097/inf.0000000000005150
Cited by: 0
References: 31

Abstract

BACKGROUND: Shiga Toxin-producing Escherichia coli -associated hemolytic uremic syndrome (STEC-HUS) remains a leading cause of acute kidney failure, worldwide. The disease often presents with acute bloody diarrhea and supportive care is the only therapeutic option; thus, early diagnosis and early management are of paramount importance. AIM: Herein, we share the results of a proactive diagnostic approach to acute bloody diarrhea in children as shown by a surveillance activity devoted to the early diagnosis of STEC infection. METHODS: Since 2010, in a well-defined area of Northern Italy (referral pediatric population of 2 million), children and teenagers (age

Fields of Study & Subjects

Escherichia coli research studies Complement system in diseases Salmonella and Campylobacter epidemiology

Publication details

Journal / source
The Pediatric Infectious Disease Journal
Volume
45
Issue
7
Pages
642–648
Publication date
28 January 2026
Language
EN