Safety and Efficacy of Intraventricular Antibiotics for Central Nervous System Infections in Children: A Single-center Observational Study

The Pediatric Infectious Disease Journal 2026 Open access

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Authors: Mona Almarzooqi, Fionnuala Ryan, Seilesh Kadambari, James Hatcher, Dulanka Silva, Sara Elizabeth Boyd, Orlagh McGarrity, Hanna Schmid
DOI: 10.1097/inf.0000000000005198
Cited by: 0
References: 7

Abstract

Intraventricular antibiotics represent a potential adjunct to intravenous antibiotics in central nervous system infections, to achieve adequate drug concentrations in cerebrospinal fluid. In our single-center experience, describing 37 treatment episodes, intraventricular antibiotics mostly targeting shunt-associated central nervous system infections were generally well tolerated and associated with rapid clearance of cerebrospinal fluid. Large randomized controlled trials are needed to better assess treatment efficacy.

Fields of Study & Subjects

Antibiotics Pharmacokinetics and Efficacy Bacterial Infections and Vaccines Cerebrospinal fluid and hydrocephalus

Publication details

Journal / source
The Pediatric Infectious Disease Journal
Volume
45
Issue
9
Pages
765–767
Publication date
26 February 2026
Language
EN