Association of Antidepressant Serotonin Transporter Affinity With Bleeding Events in a Veteran Population
Abstract
Treatment-emergent bleeding is a well-known risk with serotonergic antidepressants. Studies assessing this risk based on varying serotonergic binding affinity are limited. This report was conducted to address this gap in the literature by evaluating antidepressant-associated bleeding risks based on binding affinity to the serotonin transporter (SERT). A sample of bleeding events from 267 patients that occurred between January 1, 2018 and January 1, 2020, within a single Veterans Affairs (VA) Health Care System was retrospectively evaluated. The primary endpoint was the percentage of veterans experiencing a bleeding event while prescribed an antidepressant with high (K i ≤1), intermediate (K i >1 to
Fields of Study & Subjects
Cardiac Health and Mental Health
Potassium and Related Disorders
Gastrointestinal Bleeding Diagnosis and Treatment
Publication details
- Journal / source
- Journal of Clinical Psychopharmacology
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 46
- Issue
- 2
- Pages
- 134–139
- Publication date
- 26 January 2026
- Language
- EN