Insights into the mechanisms of drug resistance in renal cell carcinoma: from multi-omics perspective
Abstract
Renal cell carcinoma (RCC) is a prevalent malignancy of the urinary system. Despite significant advances achieved through targeted therapies and immunotherapies, therapeutic resistance remains a major obstacle to sustained clinical efficacy. This review comprehensively examines the molecular mechanisms driving resistance to both targeted therapy and immunotherapy in RCC from a multi-omics perspective. By integrating findings across diverse omics layers, we underscore the pivotal role of multi-level regulatory networks in mediating drug resistance and immune evasion. Our objective is to provide an in-depth understanding of these resistance mechanisms and to establish a theoretical framework for developing innovative therapeutic strategies aimed at overcoming resistance, thereby facilitating the advancement of precision oncology in RCC.
Fields of Study & Subjects
Renal cell carcinoma treatment
Ferroptosis and cancer prognosis
Cancer Immunotherapy and Biomarkers
Publication details
- Journal / source
- International Journal of Surgery
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 112
- Issue
- 4
- Pages
- 10311–10326
- Publication date
- 3 February 2026
- Language
- EN