Letter to the Editor “Paradoxical HDL-C/ApoA1 associations in osteoarthritis progression: a call for functional lipidomics and personalized thresholds”
Abstract
To the Editor, We approached with considerable intrigue the prospective cohort study conducted by Wang et al, which scrutinizes serum lipid metabolites as prognostic indicators for joint arthroplasty in individuals afflicted with hip/knee osteoarthritis (OA)[1]. The authors’ pioneering utilization of Fine & Gray competing-risk models unveiled counterintuitive correlations: increased levels of HDL-C and ApoA1 – lipids conventionally viewed as cardioprotective – exhibited a significant association with hastened OA progression (Sub-HR 1.05 and 1.05, respectively; P
Fields of Study & Subjects
Osteoarthritis Treatment and Mechanisms
Lipoproteins and Cardiovascular Health
Cholesterol and Lipid Metabolism
Publication details
- Journal / source
- International Journal of Surgery
- Volume
- 112
- Issue
- 6
- Pages
- 12947–12948
- Publication date
- 4 March 2026
- Language
- EN