Association of baseline D-dimer with adverse outcomes after percutaneous coronary intervention in patients with coronary heart disease: A meta-analysis

BACKGROUND: To investigate the association between baseline D-dimers (DD) and adverse outcomes after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD) by meta-analysis. METHODS: Relevant literature was obtained by searching PubMed, Web of Science, Cochrance Library, and Embase until November 2024. The hazard ratio (HR) and 95% confidence interval (CI) were pooled for each study using either a fixed or random-effects model. The clinical outcomes analyzed were all-cause mortality, cardiovascular mortality, major adverse cardiovascular events (MACE), and revascularization. RESULTS: A total of 10 articles were included in this meta-analysis. The results of meta-analysis showed that high baseline DD levels were associated with an increased risk of all-cause mortality (HR = 2.35, 95% CI: 1.78-3.10, P < .001), cardiovascular mortality (HR = 2.94, 95% CI: 1.99-4.33, P < .001), and MACE (HR = 1.74, 95% CI: 1.25-2.42, P = .001) after PCI in patients with CHD. However, no association was found between baseline DD level and revascularization risk (HR = 1.02, 95% CI: 0.76-1.37, P = .893). CONCLUSION: Baseline DD level can predict adverse clinical outcomes after PCI in patients with CHD. High baseline DD levels were significantly associated with an increased risk of all-cause mortality, cardiovascular mortality, and MACE.