Vitamin D deficiency and risk of incident atrial fibrillation/flutter: A multicenter longitudinal cohort study

Medicine 2026 Open access

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Authors: Ching‐Chung Ko, Ting-Sian Yu, Kuo-Chuan Hung, Yi-Chen Lai, Jheng-Yan Wu, I-Wen Chen
DOI: 10.1097/md.0000000000047326
Cited by: 2
References: 36

Abstract

The association between vitamin D deficiency (VDD) and incident atrial fibrillation/flutter (AF) remains controversial due to conflicting evidence from cross-sectional studies. This study assessed the association between VDD and incident AF using a large-scale, multi-institutional cohort with propensity score matching. This longitudinal cohort study utilized the TriNetX platform, analyzing individuals aged ≥40 years with 2 serum 25-hydroxyvitamin D measurements between 2010 and 2023. Patients with sustained VDD (

Fields of Study & Subjects

Vitamin D Research Studies Vitamin K Research Studies Cardiovascular Disease and Adiposity

Publication details

Journal / source
Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
105
Issue
4
Pages
e47326–e47326
Publication date
23 January 2026
Language
EN