Severe exfoliative dermatitis induced by apalutamide in a mHSPC patient: A case report
Abstract
RATIONALE: Apalutamide is a generation androgen antagonist for the treatment of metastatic hormone sensitive prostate cancer and non-metastatic castration resistant prostate cancer. Skin adverse reactions caused by apalutamide are mostly rashes and maculopapules. PATIENT CONCERNS: There are a few reports about exfoliative dermatitis caused by apalutamide. DIAGNOSES: Severe exfoliative dermatitis induced by apalutamide. INTERVENTIONS: Gamma globulin, cefoperazone sulbactam sodium, albumin, ebastine, loratadine, hydrocortisone cream, and 3% boric acid lotion. OUTCOMES: Whole-body skin was red, without exudation, and with a small amount of desquamation. LESSONS: The incidence of exfoliative dermatitis due to apalutamide is low but severe, and if a serious adverse skin reaction is suspected, apalutamide needs to be discontinued immediately and treated accordingly.
Fields of Study & Subjects
Chemotherapy-related skin toxicity
Prostate Cancer Treatment and Research
Colorectal Cancer Treatments and Studies
Publication details
- Journal / source
- Medicine
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 105
- Issue
- 7
- Pages
- e47428–e47428
- Publication date
- 13 February 2026
- Language
- EN