Construction and evaluation of a SPECT-based radiomics nomogram for predicting the therapeutic response to radioactive iodine in patients with differentiated thyroid carcinoma
Abstract
Differentiated thyroid carcinoma (DTC) frequently requires radioactive iodine therapy, yet accurately predicting short-term therapeutic response remains challenging. Radiomics offers a means to quantify intratumoral heterogeneity from routine imaging. We aimed to develop and internally validate a Single-photon emission computed tomography (SPECT)-based radiomics nomogram for predicting 6-month response after RAI in DTC. We conducted a single-center retrospective study of 420 patients with DTC. Post-therapy 131I SPECT/CT images were processed to extract image biomarker standardisation initiative-aligned radiomic features in MATLAB; features passing reproducibility (ICC ≥ 0.80) and redundancy (|r|
Fields of Study & Subjects
Radiomics and Machine Learning in Medical Imaging
Thyroid Cancer Diagnosis and Treatment
Medical Imaging Techniques and Applications
Publication details
- Journal / source
- Medicine
- Volume
- 105
- Issue
- 7
- Pages
- e47658–e47658
- Publication date
- 13 February 2026
- Language
- EN