Role of uridine phosphorylase 1 in cancer: A comprehensive pan-cancer analysis highlighting its prognostic and therapeutic potential
Abstract
Uridine phosphorylase 1 (UPP1) is implicated in numerous cancers, yet lacks comprehensive evaluation across cancer types. This pan-cancer study aims to elucidate UPP1's roles and establish its potential as a biomarker and therapeutic target. This study analyzes the expression, genetic alterations, DNA methylation, and prognostic significance of UPP1 across 33 cancer types using multiple cancer genomics databases. We utilized databases such as TIMER, GEPIA, UALCAN, cBioPortal, and Kaplan-Meier Plotter to conduct a systematic analysis of UPP1 involving gene expression, genetic alteration patterns, promoter methylation, and survival impact in various cancers. UPP1 showed high expression in 19 out of 33 cancers and was down-regulated in 4. Notably, high UPP1 expression was associated with poor prognosis in 8 cancer types (OS: hazard ratios >1, P
Fields of Study & Subjects
Ferroptosis and cancer prognosis
RNA modifications and cancer
Bladder and Urothelial Cancer Treatments
Publication details
- Journal / source
- Medicine
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 105
- Issue
- 8
- Pages
- e47685–e47685
- Publication date
- 20 February 2026
- Language
- EN