Association between plasma ceramide levels and endothelial dysfunction in patients with acute coronary syndrome: A prospective observational study

Medicine 2026 Open access

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Authors: Jie Chen, Yang Cheng, Xingxuan Cai, Mingyi Wang, Zhengbin Zhang, Simeng Wei, Shanshan Zhou, Yundai Chen
DOI: 10.1097/md.0000000000048341
Cited by: 1
References: 37

Abstract

Ceramides are bioactive lipids that contribute to endothelial dysfunction (ED) by promoting inflammation and oxidative stress. However, whether ceramide levels are linked to peripheral microvascular endothelial function in patients with acute coronary syndrome (ACS) is not well understood. We conducted a prospective observational study of 80 ACS patients undergoing percutaneous coronary intervention at a single center. Peripheral endothelial function was assessed using the EndoPAT2000® system. ED was defined as a reactive hyperemia index

Fields of Study & Subjects

Sphingolipid Metabolism and Signaling Cardiovascular Health and Disease Prevention Inflammation biomarkers and pathways

Publication details

Journal / source
Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
105
Issue
16
Pages
e48341–e48341
Publication date
17 April 2026
Language
EN