Global research trends on intra-arterial chemotherapy for retinoblastoma: A bibliometric and visualized study

PURPOSE: This study aims to determine the bibliometric characteristics of scientific articles on intra-arterial chemotherapy for retinoblastoma worldwide. METHODS: The Web of Science database was used to conduct a comprehensive search strategy, which included all languages, countries or regions, affiliations, journals, research areas. The search ultimately yielded 256 articles that met the predefined inclusion criteria and were manually reviewed. The study employed a bibliometric analysis using quantitative bibliometric indicators and network analysis with co-authorship and co-occurrence of terms, using the bibliometrix package in R and VOSviewer, respectively. RESULTS: The number of publications has been increasing since the first publication in 2010, with the largest number in 2021 (36 articles). The average number of citations per document was 13.32, and the annual growth rate was 5.38%. The most prolific country and authors were from the United States. Carol Lally Shields had the most contributions (53 articles), and the most cited study was published by Gobin et al in 2011. The journal with the most publications was JAMA Ophthalmology. The most commonly used keywords were Retina, Enucleation, and Periocular around 2016, while Radiation, Advanced age, and External carotid artery were commonly used around 2020. CONCLUSIONS: The United States is the most prolific country in this topic, with a large publication output but a low collaboration among other countries. Low- and middle-income countries should also be encouraged to implement research to contribute to the advancement of knowledge on intra-arterial chemotherapy for retinoblastoma.