A Case of EBV-Driven Histiocytic Sarcoma as PTLD in a Pediatric Heart Transplant Patient

Journal of Pediatric Hematology/Oncology 2026

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Authors: Kasey Chelemedos, Nishma Shah, Kaitlyn Quijano, Nikhila Hari, Ahmed Bendari, Rylen Stratford, Surita Banerjee, Danielle Weiss, Amanda Baker, Andrew Joshua Kobets, Adit L. Tal
DOI: 10.1097/mph.0000000000003171
Cited by: 0
References: 22

Abstract

Post-transplant lymphoproliferative disorders (PTLD) are typically EBV-driven neoplasms that occur after transplantation. Histiocytic sarcomas (HS) are rare malignancies. PTLD HS cases are even rarer. We discuss a case of multiorgan EBV+ HS PTLD in a pediatric male with a history of orthotopic heart transplant. He was initially treated broadly, then narrowed to disease-targeted therapy. Surveillance imaging showed improvement of his diffuse body lesions, but new leptomeningeal enhancements were identified. He developed neurological deterioration and succumbed to his disease. This is a rare case of PTLD manifesting as an EBV-driven HS with meningeal metastasis unresponsive to targeted therapy despite multiorgan improvement elsewhere.

Fields of Study & Subjects

Viral-associated cancers and disorders Histiocytic Disorders and Treatments Autoimmune and Inflammatory Disorders Research

Publication details

Journal / source
Journal of Pediatric Hematology/Oncology
Volume
48
Issue
2
Pages
88–93
Publication date
4 February 2026
Language
EN