Effectiveness of thiazide diuretics in patients with hypertension: a systematic review and meta-analysis

Annals of Medicine and Surgery 2026 Open access

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Authors: Taimoor Ashraf, FNU Chandni, Fnu Nancy, Nisha Devi, Deepa Bai, Ramsha Waseem, Maheen Jabbar, Muskan Turesh, Shah Dev, Rabia Bint I Zafar, Sadia Manan, Fatima Jabbar
+3 more Iqra Maryam, Zara Naveed, Sayed Jawad
DOI: 10.1097/ms9.0000000000004668
Cited by: 1
References: 12

Abstract

Background Thiazide diuretics are commonly prescribed for the treatment of hypertension (HTN). However, the comparative efficacy and safety of hydrochlorothiazide (HCTZ) versus chlorthalidone (CTD) in managing patients with HTN remain unclear. Materials and Methods A comprehensive literature search was performed using two electronic databases, MEDLINE and Cochrane, from their inception through November 2024. The aim was to identify randomized controlled trials or observational double-arm studies assessing the effects of HCTZ versus CTD on cardiovascular outcomes and safety in patients with HTN. Outcomes were reported as hazard ratios (HRs) with 95% confidence intervals (CIs), and analyses were conducted using a random effects model. A P -value of

Fields of Study & Subjects

Blood Pressure and Hypertension Studies Sodium Intake and Health Electrolyte and hormonal disorders

Publication details

Journal / source
Annals of Medicine and Surgery
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
88
Issue
2
Pages
1706–1712
Publication date
6 January 2026
Language
EN