Kimura’s Disease Complicated by Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

INTRODUCTION: Kimura's disease is a chronic inflammatory disorder, while cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebral small vessel disease. CASE REPORT: A 56-year-old Chinese male with a 6-year history of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy was admitted due to recurrent cerebral infarcts. He also had a concurrent diagnosis of Kimura's disease accompanied by hypereosinophilia and elevated serum immunoglobulin E levels. Although the patient had been on oral antiplatelet therapy, no preventive treatment had been previously administered for the hypereosinophilia or high immunoglobulin E levels. We conducted follow-up to track disease progression and to review the management approach, including its strengths and shortcomings. CONCLUSION: This case represents a rarely reported instance of Kimura's disease coexisting with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. It underscores the importance of differentiating stroke etiologies and illustrates the potential for complications when hypereosinophilic conditions are left untreated.