Interrelationship Between SHH and TGF-beta in the Formation of Odontomas

Applied immunohistochemistry & molecular morphology 2026

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Authors: Glória Maria de França, Cláudia Nunes Oliveira, Prof. Roseana De Almeida Freitas, Pedro Paulo de Andrade Santos, Hébel Cavalcanti Galvão
DOI: 10.1097/pai.0000000000001300
Cited by: 0
References: 24

Abstract

The SHH signaling regulates cell proliferation in the ectomesenchyme, thus controlling tooth morphogenesis, while TGF-ß and bone morphogenetic proteins (BMPs) have been associated with reactionary and reparative dentinogenesis. The aim of this study was to investigate the role of signaling proteins in odontogenesis and odontoma formation. In this retrospective cross-sectional study, we analyzed the immunohistochemical expression of TGF-ß, BMP4, and SHH pathway proteins in 23 compound odontomas, 21 complex odontomas, and 17 tooth germs. The results demonstrated immunoexpression of BMP4, especially in the ectomesenchyme of complex odontomas (median=33.7; P

Fields of Study & Subjects

dental development and anomalies Oral and Maxillofacial Pathology Hedgehog Signaling Pathway Studies

Publication details

Journal / source
Applied immunohistochemistry & molecular morphology
Volume
34
Issue
2
Pages
77–85
Publication date
12 January 2026
Language
EN