Crypt Dysplasia is a Risk Factor for the Development of High-Grade Dysplasia/Adenocarcinoma in Barrett Esophagus

The American Journal of Surgical Pathology 2026

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Authors: Vikram Deshpande, Melissa M. Zhao, Azfar Neyaz, Steffen Rickelt, Chih-Ping Mao, Sahar Hosseini, Robert Daniel Odze, Deepa T. Patil
DOI: 10.1097/pas.0000000000002504
Cited by: 0
References: 25

Abstract

The aim of this study was to perform a detailed clinical and pathologic analysis of biopsies from 180 BE patients with the goal of understanding the clinical significance and outcome of patients diagnosed with crypt dysplasia (CD). Biopsies from 58 progressors and 122 nonprogressors (372 biopsies) were graded by 3 gastrointestinal pathologists. A consensus biopsy diagnosis (agreement by ≥2 pathologists) was used for outcome analysis. The overall diagnostic agreement among all 3 observers was high (0.75) and was observed in 83.9% cases, with a moderate level of agreement (0.44) noted for CD. BE progressors had a significantly higher proportion of index biopsies with CD (17% vs. 2%) and LGD (9% vs. 0%; overall P

Fields of Study & Subjects

Esophageal Cancer Research and Treatment Eosinophilic Esophagitis Esophageal and GI Pathology

Publication details

Journal / source
The American Journal of Surgical Pathology
Volume
50
Issue
3
Pages
356–365
Publication date
9 January 2026
Language
EN