Clinical Outcomes and Prognostication of CRTC1::TRIM11 Fusion Cutaneous Tumors

The American Journal of Surgical Pathology 2026

View at publisher
Authors: NITHYA S. TRICHY, Jonathan Braat, Lindsay J. Holic, Shantel Olivares, Klaus J. Busam, Alison Cheah, Jeffrey M. Cloutier, Damian Collins, Pranav Dorwal, Arnaud de la Fouchardière, John Gross, Eleni Ieremia
+10 more Ivy John, Arivarasan Karunamurthy, Konstantinos Linos, Ata S. Moshiri, José A. Salinas, Sara Shalin, Campbell Stewart, Khin Thway, Gillian Weston, Pedram Gerami
DOI: 10.1097/pas.0000000000002575
Cited by: 1
References: 38

Abstract

Since the original description of CRTC1::TRIM11 fusion cutaneous tumors (CTCT) in 2018, an increasing number of cases with metastatic behavior have been reported, yet there are limited studies analyzing prognostic parameters. This expanding data set presents an opportunity for reappraisal of clinical behavior. We present a series of 21 cases with detailed morphologic, molecular, clinical outcomes, and therapeutic response data. We utilize this data and a meta-analysis of all the cases in the literature to assess potential prognostic parameters to assist in clinical management. Primary tumors resulting in metastasis were larger ( P =0.038), had higher mitotic counts ( P

Fields of Study & Subjects

Histiocytic Disorders and Treatments Cutaneous lymphoproliferative disorders research Polyomavirus and related diseases

Publication details

Journal / source
The American Journal of Surgical Pathology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
50
Issue
9
Pages
1015–1028
Publication date
3 June 2026
Language
EN