Changes in cardiovascular and metabolic risk scores after switching to DOR/3TC/TDF, DTG/3TC or BIC/FTC/TAF: results from a multicenter Italian cohort

OBJECTIVE: To assess changes of cardiovascular risk scores and metabolic scores after switching to DOR/3TC/TDF (DOR group), DTG/3TC (DTG group) or BIC/FTC/TAF (BIC group). METHODS: We analyzed data from 1069 virologically suppressed people with HIV (PWH), collecting clinical history and laboratory parameters at baseline (date of switch) and 48 weeks of follow-up. In eligible PWH, we calculated body mass index (BMI), SCORE-2 for cardiovascular risk assessment and the metabolic score for insulin resistance (METS-IR) at both timepoints and performed linear mixed model for repeated measures to measure changes in parameters, while using linear regression analyses to search for predictors of change. RESULTS: After 48 weeks, we observed significant changes in median SCORE-2 in all groups: there were increases of +0.12 in the DTG group ( P = 0.021) and +0.30 in the BIC group (