Addition of estrogen for luteal phase support in women with sub-optimal or poor response after an antagonist protocol: a cohort study

Reproductive and Developmental Medicine 2026 Open access

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Authors: Li-Juan Fan, Wen Wen, Ning Ning, T. Wang, Ting Sun, Juan-Zi Shi, Na Li
DOI: 10.1097/rd9.0000000000000153
Cited by: 0
References: 25

Abstract

Objective: To evaluate the potential benefits of estradiol (E 2 ) supplementation as luteal phase support (LPS) on reproductive outcomes in women who exhibited sub-optimal or poor ovarian response after a gonadotropin-releasing hormone antagonist (GnRH-ant) protocol and fresh embryo transfer. Methods: In this retrospective study, we assessed the potential benefits of E 2 supplementation as LPS on reproductive outcomes in 4992 women who met the following criteria: 1) age

Fields of Study & Subjects

Ovarian function and disorders Reproductive Biology and Fertility Reproductive Health and Technologies

Publication details

Journal / source
Reproductive and Developmental Medicine
Volume
10
Issue
3
Pages
194–199
Publication date
2 January 2026
Language
EN