Ultra-Sensitive Detection of Bone Metastasis From Accessory Breast Cancer Using HER2 PET/CT: A Case Report
Abstract
We presented the imaging findings of 18 F-FDG and 68 Ga-HER2 affibody PET/CT in a 52-year-old woman with HER2-positive accessory breast cancer in the right axilla. 18 F-FDG and HER2 PET/CT showed avid uptake of multiple axillary lesions. HER2 PET/CT identified extensive bone metastases with intense uptake, while the ⁹⁹ᵐTc-MDP whole bone scan was negative, and only a few bone lesions with mild tracer uptake were detected by 18 F-FDG PET/CT. Following 6 cycles of the TCbHP regimen, the axillary lesions markedly reduced. This case demonstrates that HER2 PET/CT enables more sensitive detection of HER2-positive lesions, thereby allowing for precise staging and guiding HER2-targeted therapy.
Fields of Study & Subjects
Medical Imaging Techniques and Applications
Radiopharmaceutical Chemistry and Applications
HER2/EGFR in Cancer Research
Publication details
- Journal / source
- Clinical Nuclear Medicine
- Volume
- 51
- Issue
- 4
- Pages
- 362–364
- Publication date
- 15 January 2026
- Language
- EN