High 68Ga-FAPI-04 and Low 18F-FDG Uptake in a Patient With Hepatic Epithelioid Hemangioendothelioma
Abstract
We report a rare case of multifocal hepatic epithelioid hemangioendothelioma (HEHE) evaluated using [⁶⁸Ga]Ga-FAPI-04 and [¹⁸F]FDG PET/CT. Abdominal CT revealed multiple hepatic masses with mild peripheral enhancement and central necrosis. On [¹⁸F]FDG PET/CT, the lesions demonstrated uptake similar to or faint compared with normal liver parenchyma, whereas [⁶⁸Ga]Ga-FAPI-04 PET/CT showed intense tracer accumulation with a high tumor-to-background ratio in all hepatic lesions, without evidence of extrahepatic involvement. This case illustrates the potential diagnostic advantage of FAPI imaging in detecting and characterizing hepatic vascular tumors with low FDG avidity.
Fields of Study & Subjects
Peptidase Inhibition and Analysis
Vascular Tumors and Angiosarcomas
Radiopharmaceutical Chemistry and Applications
Publication details
- Journal / source
- Clinical Nuclear Medicine
- Volume
- 51
- Issue
- 8
- Pages
- e694–e696
- Publication date
- 20 January 2026
- Language
- EN