Comparable Diagnostic Performance of 68Ga-FAPI and 18F-FDG PET/CT in Perineal Rhabdomyosarcoma
Abstract
A 14-year-old boy with inguinal lymphadenopathy and scrotal swelling was diagnosed with perineal rhabdomyosarcoma (RMS) via lymph node biopsy. Initial staging with 18 F-FDG PET/CT revealed hypermetabolic lymph nodes and a perineal mass overlooked on contrast-enhanced CT assessment. A complementary 68 Ga-FAPI-46 PET/CT scan demonstrated comparable lesion detection with higher target-to-background contrast in the primary tumor located in the perineum. This case highlights the diagnostic value of FAP-targeted imaging in pediatric RMS and supports its potential theranostic role in soft tissue sarcomas, expanding current understanding of FAPI avidity in this rare tumor subtype.
Fields of Study & Subjects
Peptidase Inhibition and Analysis
Sarcoma Diagnosis and Treatment
Medical Imaging Techniques and Applications
Publication details
- Journal / source
- Clinical Nuclear Medicine
- Volume
- 51
- Issue
- 8
- Pages
- e699–e701
- Publication date
- 4 February 2026
- Language
- EN