Early Detection of Neuroblastoma Recurrence on 18F mFBG PET
Abstract
A patient with neuroblastoma was assessed to be in remission based on clinical and standard-of-care imaging assessments, including a negative I-123 m IBG scan. Patient underwent 18 F m FBG PET/CT imaging on the same day as I-123 m IBG scan as part of a clinical trial (NCT: 04724369), which showed abnormal focal uptake suspicious for lesion in the skull. Patient underwent surveillance and follow-up with standard imaging. I-123 m IBG SPECT/CT at 3 months showed no abnormalities in the skull, but repeat examination at 6 months showed positive uptake corresponding to 18 F m FBG. Recurrent neuroblastoma was confirmed on MRI. This example indicates that 18 F m FBG PET identified neuroblastoma recurrence 6 months earlier than the current standard-of-care imaging.
Fields of Study & Subjects
Neuroblastoma Research and Treatments
Cancer
Hypoxia
and Metabolism
Medical Imaging Techniques and Applications
Publication details
- Journal / source
- Clinical Nuclear Medicine
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 51
- Issue
- 7
- Pages
- 580–582
- Publication date
- 9 February 2026
- Language
- EN