Radiation-Induced Side Effects to the Skin Due to 177Lu-PSMA Extravasation

Clinical Nuclear Medicine 2026

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Authors: Heather Corveleyn, Lynn De Mey, Laurens Raes, Amelientje Bracke, Sophie Bourgeois
DOI: 10.1097/rlu.0000000000006354
Cited by: 1
References: 9

Abstract

We report a case with clinical side effects related to extravasation of 177 Lu-PSMA (estimated activity of 2.25 GBq) after administration via the cubital vein. After initial cooling (±10 min), the patient was asked to elevate and mobilize the arm. Five weeks post-injection (p.i.), the patient reported localized pruritus. An erythematosqualous plaque with lichenification was observed. At 9 weeks p.i., a slight inflammatory hyperpigmentation remained; all other symptoms had disappeared.

Fields of Study & Subjects

Chemotherapy-related skin toxicity Nonmelanoma Skin Cancer Studies Cutaneous lymphoproliferative disorders research

Publication details

Journal / source
Clinical Nuclear Medicine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
51
Issue
5
Pages
426–428
Publication date
9 February 2026
Language
EN