18F-DOPA PET Silence in High-grade Glioma Subtype F
Abstract
The 2021 WHO classification distinguishes adult-type diffuse gliomas as astrocytoma, oligodendroglioma, and glioblastoma. Recently, a new epigenetic subtype-high-grade glioma IDH-wildtype, subtype F (HGG-F)-has been described, characterized by gliomatosis-like infiltration, low proliferative index, and unexpectedly prolonged survival despite a grade 4 methylation profile. We report the first HGG-F evaluated with 18 F-DOPA PET. Despite extensive FLAIR-hyperintense lesions, tracer distribution was entirely normal. This "amino acid PET silence," contrasting with the typically intense uptake in high-grade gliomas, together with the gliomatosis-like MRI appearance, should raise suspicion for this emerging subtype.
Fields of Study & Subjects
Glioma Diagnosis and Treatment
Medical Imaging Techniques and Applications
Radiomics and Machine Learning in Medical Imaging
Publication details
- Journal / source
- Clinical Nuclear Medicine
- Volume
- 51
- Issue
- 8
- Pages
- e728–e729
- Publication date
- 4 February 2026
- Language
- EN