18F-Fluciclovine (18F-FACBC) PET/MRI Findings in Tumefactive Demyelinating Lesion

Clinical Nuclear Medicine 2026

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Authors: Akihiko Sakata, Shigeki Takada, Yasuhide Takeuchi, Yoshiki Arakawa, Yuji Nakamoto
DOI: 10.1097/rlu.0000000000006407
Cited by: 0
References: 7

Abstract

A 28-year-old man presented with acute onset dysarthria and right facial droop. MRI revealed a horseshoe-shaped mass in the left frontal lobe, and tumefactive demyelinating lesion (TDL) was suspected. Despite steroid pulse therapy, follow-up imaging demonstrated lesion enlargement, raising concern for malignancy. 18F-Fluciclovine (18F-FACBC) PET/MRI showed moderate tracer accumulation. Surgical resection was performed, and the diagnosis of TDL was confirmed. This represents the first reported case of TDL evaluated with 18F-Fluciclovine PET imaging. The discordance between moderate tracer uptake and rapid lesion growth may be useful for differentiating TDL from glioma.

Fields of Study & Subjects

Medical Imaging Techniques and Applications Multiple Sclerosis Research Studies Glioma Diagnosis and Treatment

Publication details

Journal / source
Clinical Nuclear Medicine
Volume
51
Issue
9
Pages
e779–e781
Publication date
2 March 2026
Language
EN