Theranostic Application of FAPI in Advanced Laryngeal Squamous Cell Carcinoma: 99mTc-FAPI-46 SPECT/CT Guided 177Lu-FAPI-2286 Therapy
Abstract
A 47-year-old man with advanced laryngeal squamous cell carcinoma had received chemotherapy but subsequently developed widespread skeletal metastases identified on bone scintigraphy. He underwent 99m Tc-FAPI-46 SPECT/CT, which demonstrated FAPI uptake in primary laryngeal tumor, cervical soft tissue involvement, and extensive skeletal metastases, accurately reflecting the overall disease burden. Due to disease progression despite chemotherapy and for palliative management of bone pain, he was enrolled in a clinical trial and received 177 Lu-FAPI-2286 radioligand therapy. Post-treatment imaging confirmed tracer accumulation in all known disease sites, highlighting the clinical utility of FAPI-based imaging and its theranostic potential in advanced laryngeal carcinoma.
Fields of Study & Subjects
Peptidase Inhibition and Analysis
Orthopedic Infections and Treatments
Connective tissue disorders research
Publication details
- Journal / source
- Clinical Nuclear Medicine
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 51
- Issue
- 9
- Pages
- e811–e812
- Publication date
- 15 May 2026
- Language
- EN