Humanized MISTRG6 Mice: A Relevant Translational Model for Examining Early Bone Marrow Changes in Acute CLP Sepsis

Shock 2026 Open access

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Authors: Kacper Bielak, Magdalena Bandyszewska, Magdalena Ambrożek-Latecka, Kosinska-Kaczynska Katarzyna, Marcin Filip Osuchowski, Tomasz Skirecki, Grazyna Anna Hoser
DOI: 10.1097/shk.0000000000002660
Cited by: 1
References: 11

Abstract

Humanized MISTRG6 mice reveal early bone marrow remodeling in CLP sepsis, including altered HSPC dynamics and niche composition. This model is highly translational for studying human hematopoiesis and therapeutic interventions after CLP.

Fields of Study & Subjects

Platelet Disorders and Treatments Inflammation biomarkers and pathways Complement system in diseases

Publication details

Journal / source
Shock
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
65
Issue
3
Pages
551–554
Publication date
2 January 2026
Language
EN