Donor Warm Ischemia Time Modifies Susceptibility to Cold Ischemia in Donation After Circulatory Death Kidney Allografts Under Hypothermic Machine Perfusion

Transplantation 2026

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Authors: Toshihiro Nakayama, Antony M. Attia, Daniel J. Ahn, Yutaka Endo, Randeep S Kashyap, Roberto Hernández-Alejandro, Kazunari Sasaki, Yuki Bekki
DOI: 10.1097/tp.0000000000005758
Cited by: 1
References: 41

Abstract

BACKGROUND: Donation after circulatory death (DCD) kidneys are exposed to donor warm ischemia time (dWIT) in addition to cold ischemia. Although porcine studies suggest synergy between these insults, evidence in clinical transplantation is limited. METHODS: Adult DCD kidney-only transplants performed using hypothermic machine perfusion (n = 28 698) in the United Network for Organ Sharing database (January 1, 2015, to December 31, 2023) were included. We performed 1:1:1 propensity score matching across 3 cold ischemia time (CIT) categories (short,

Fields of Study & Subjects

Organ Transplantation Techniques and Outcomes Renal Transplantation Outcomes and Treatments Renal and Vascular Pathologies

Publication details

Journal / source
Transplantation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Volume
110
Issue
8
Pages
e1731–e1740
Publication date
28 May 2026
Language
EN