Perivascular Diffusivity Suggests Dynamic and Modifiable Glymphatic Transit in Idiopathic Intracranial Hypertension
Abstract
BACKGROUND: Preliminary work suggests that glymphatic transit is abnormal and dynamic in idiopathic intracranial hypertension (IIH), although its incomplete characterization across the disease course has led to debate as to its pathophysiologic relevance. We seek to clarify whether glymphatic transit varies across IIH's disease course, correlates with intracranial pressure, and might be measured radiographically to aid diagnosis. METHODS: Diffusion tensor imaging along the perivascular space (ALPS) was used to measure perivascular diffusivity and generate indices of glymphatic transit (ALPS-indices). We studied healthy controls and participants with IIH cross-sectionally, the latter stratified into untreated, treated, or cured IIH. Participants with untreated IIH were substratified as "acute" if imaged
Fields of Study & Subjects
Cerebrospinal fluid and hydrocephalus
Neurosurgical Procedures and Complications
Cerebral Venous Sinus Thrombosis
Publication details
- Journal / source
- Journal of Neuro-Ophthalmology
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Volume
- 46
- Issue
- 1
- Pages
- 105–112
- Publication date
- 6 January 2026
- Language
- EN