Telomeres and Telomerase

Cold Spring Harbor Perspectives in Biology 2026 Preprint Open access

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Authors: Julia Promisel Cooper, Eros Lazzerini Denchi, Joachim Lingner, Hilda A. Pickett
DOI: 10.1101/cshperspect.a041972
Cited by: 1
References: 22

Abstract

Telomeres represent a molecular nexus where genome stability, aging, disease susceptibility, and regenerative potential converge. Advances in understanding how telomeres are replicated, protected, and repaired now inform fundamental questions about human lifespan, tissue renewal, the molecular origins of age-related decline, and cancer evolution. This volume presents an integrated collection of perspectives spanning telomere architecture, replication dynamics, telomere-driven genome instability, and telomere maintenance by telomerase and Alternative Lengthening of Telomeres (ALT), while also charting new therapeutic directions grounded in telomere biology. Drawing on molecular, structural, organismal, and clinical research, this collection showcases a field in rapid motion, reshaping our view of regeneration, aging, and disease.

Fields of Study & Subjects

Telomeres Telomerase and Senescence Nuclear Structure and Function Epigenetics and DNA Methylation

Publication details

Journal / source
Cold Spring Harbor Perspectives in Biology
Publisher
Cold Spring Harbor Laboratory
Volume
18
Issue
8
Pages
a041972–a041972
Publication date
9 February 2026
Language
EN
Document type
Preprint