Roadmap for Condensates in Cell Biology

PRX Life 2026 Open access

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Authors: Anonymous, Sebastian Aland, Stefano Bo, Steven Boeynaems, Danfeng Cai, Serena Carra, Lindsay B. Case, Hue Sun Chan, Jorge R. Espinosa, Trevor K. GrandPre, Alexander Y. Grosberg, Ivar S. Haugerud
+29 more William M. Jacobs, Jerelle A. Joseph, Frank Jülicher, Kurt Kremer, Guido L. A. Kusters, Liedewij Laan, Keren Lasker, Kathrin S. Laxhuber, Hyun O. Lee, Kathy F. Liu, Dimple Notani, Yicheng Qiang, Paul J. Robustelli, Leonor Saiz, Omar Abdullah Saleh, Helmut Schießel, Jeremy D. Schmit, Meng Shen, Krishna Shrinivas, Antonia Statt, Andrés R. Tejedor, Tatjana Trcek, Christoph Andreas Weber, Stephanie C. Weber, Ned S. Wingreen, Huaiying Zhang, Yaojun Zhang, Huan‐Xiang Zhou, David Zwicker
DOI: 10.1103/3b2k-ftwx
Cited by: 1
References: 96

Abstract

Biomolecular condensates govern essential cellular processes yet elude description by traditional equilibrium models. This roadmap, distilled from structured discussions at a workshop and reflecting the consensus of its participants, clarifies key concepts for researchers, funding bodies, and journals. After unifying terminology that often separates disciplines, we outline the core physics of condensate formation, review their biological roles, and identify outstanding challenges in nonequilibrium theory, multiscale simulation, and quantitative in-cell measurements. We close with a forward-looking outlook to guide coordinated efforts toward predictive, experimentally anchored understanding and control of biomolecular condensates.

Fields of Study & Subjects

RNA Research and Splicing Nanopore and Nanochannel Transport Studies Protein Structure and Dynamics

Publication details

Journal / source
PRX Life
Publisher
American Physical Society (APS)
Volume
4
Issue
3
Publication date
10 July 2026
Language
EN