Modelling of radiation damage and beam-induced heating of room-temperature samples at extremely high flux MX beamlines
Abstract
The upgrade of the third-generation synchrotrons to diffraction-limited storage rings will enable a gain of up to two orders of magnitude in brilliance and further enable the creation of multiple macromolecular crystallography (MX) beamlines capable of delivering fluxes in excess of 1 × 10 15 photons s −1 , here called extremely high flux (EHF) MX beamlines. These beamlines, such as ID29 at ESRF-EBS, BioCARS at APS-U and MicroMAX at MAX IV, have all been either partly or solely geared towards delivering time-resolved MX experiments at room temperature and realizing microsecond time resolutions. Given the uncharted territory of using dose rates in excess of 50 GGy s −1 at many facilities, this article examines some of the expected consequences, suggesting that considerable attention should be paid to beam heating effects for crystals
Fields of Study & Subjects
Enzyme Structure and Function
Crystallography and Radiation Phenomena
Advanced Electron Microscopy Techniques and Applications
Publication details
- Journal / source
- IUCrJ
- Publisher
- International Union of Crystallography (IUCr)
- Volume
- 13
- Issue
- 2
- Pages
- 184–197
- Publication date
- 12 February 2026
- Language
- EN