Synthesis and crystal structure of HDAC6 selective inhibitor of N -hydroxy-4-{2-[(2-hydroxyethyl)(phenyl)amino]-2-oxoethyl}benzamide monohydrate (HPOB·H 2 O)
Abstract
The synthesis and crystal structure of the title compound N -hydroxy-4-{2-[(2-hydroxyethyl)(phenyl)amino]-2-oxoethyl}benzamide monohydrate ( HPOB · H 2 O ) is reported. The water molecule is positionally disordered at 106 K. The complex crystallizes with monoclinic P 2 1 / n symmetry, and the core of the molecule is relatively planar with the two aryl substituents rotated out of the plane. This structure highlights how HPOB · H 2 O has a hydroxamate moiety that adopts a Z conformation.
Fields of Study & Subjects
Histone Deacetylase Inhibitors Research
Chemical Synthesis and Analysis
Crystal structures of chemical compounds
Publication details
- Journal / source
- Acta Crystallographica Section E Crystallographic Communications
- Volume
- 82
- Issue
- 2
- Pages
- 132–137
- Publication date
- 6 January 2026
- Language
- EN