An analogue of indapamide: crystal structure and Hirshfeld surface analysis of 3-chloro-4-( N , N -diethynylsulfamoyl)- N -(2-methylindolin-1-yl)benzamide

Acta Crystallographica Section E Crystallographic Communications 2026 Open access

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Authors: Youssef Ramli, Wedad Al Garadi, El Mokhtar Essassi, Camille Kalonji Mubengayi, Abdulsalam Alsubari, Joel T. Mague
DOI: 10.1107/s2056989026003580
Cited by: 1
References: 12

Abstract

The title molecule, C 22 H 20 ClN 3 O 3 S, adopts a shallow cup-shaped conformation with the chlorobenzamide portion as the bottom. A puckering analysis of the five-membered ring indicates an envelope conformation. In the crystal, helical chains along the a -axis direction are formed by N—H...O hydrogen bonds reinforced by C—H...π(ring) and weak π-stacking interactions. No directed interactions between chains appear to exist. A Hirshfeld surface analysis was performed.

Fields of Study & Subjects

Crystal structures of chemical compounds Synthesis and Catalytic Reactions Synthesis of heterocyclic compounds

Publication details

Journal / source
Acta Crystallographica Section E Crystallographic Communications
Publisher
International Union of Crystallography (IUCr)
Volume
82
Issue
5
Pages
454–458
Publication date
8 April 2026
Language
EN