Foundation Model Enhanced Hierarchical Learning for White Blood Cell Classification

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Authors: Fan Xiao, Zirui Chen, Jilan Xu, Junlin Hou
Cited by: 1
References: 12

Abstract

White blood cell (WBC) classification is essential for diagnosing hematological disorders, but automated methods face challenges from data heterogeneity and class imbalance. In this work, we propose a hierarchical deep learning framework for 13-class WBC classification. To address domain shift from various imaging conditions, we fine-tune foundation models and apply pseudo-labeling on unlabeled test samples. For severe class imbalance, we introduce a specialized pipeline combining binary voting and exemplar matching to improve rare subtype recognition. Our method achieves a macro F1 score of 0.77682 on the WBCBench 2026 dataset, demonstrating its effectiveness on heterogeneous data and clinically significant minority classes.

Fields of Study & Subjects

Digital Imaging for Blood Diseases Machine Learning and ELM Face and Expression Recognition

Publication details

Journal / source
2026 IEEE 23rd International Symposium on Biomedical Imaging (ISBI)
Publisher
IEEE
Pages
1–4
Publication date
8 April 2026