29.6 A 65nm CMOS Hydrogel-Based Dual Fluorescence Sensor for Bioavailable Phosphorus Detection

Digest of technical papers/Digest of technical papers - IEEE International Solid-State Circuits Conference 2026

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Authors: Ting-Yu Cheng, Raj S. Mukkamala, Reinaldo E. Alcalde, Mohamadamin Panahandeh, Akshit Agarwal, Julia A. Kornfield, Dianne K. Newman, Azita Emami
DOI: 10.1109/isscc49663.2026.11409129
Cited by: 0
References: 10

Abstract

A hydrogel-based single-culture dual-fluorescence sensor is presented for bioavailable phosphorus (P) detection. The sensor achieves 6.6fA sensitivity with a 15.5 dB SNR and an output noise of 1.97 mV at 182 ms integration time. A large dynamic range is enabled through high-precision automatic background calibration with a coarse and fine control loop. The sensor was validated using hydrogels embedded with a bioreporter strain and successfully detected both P limitation and cell viability.

Fields of Study & Subjects

Analytical Chemistry and Sensors Biosensors and Analytical Detection Analog and Mixed-Signal Circuit Design

Publication details

Journal / source
Digest of technical papers/Digest of technical papers - IEEE International Solid-State Circuits Conference
Pages
508–510
Publication date
15 February 2026
Language
EN