A CMOS Neural Probe with 1280 Electrodes and 88 Emission Sites Featuring Thermo-Optic Switching and on-Chip Calibration for Dual-Wavelength Optogenetics

2026 IEEE International Solid-State Circuits Conference (ISSCC) 2026

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Authors: Xiaolin Yang, Pieter Neutens, Alexis Humblet, Chutham Sawigun, John O'Callaghan, Thijs Peter Joseph Geurts, Zheyi Li, Yaroslav S. Gubin, Koen De Munck, Harrie A. C. Tilmans, Anabel De Proft, Barundeb Dutta
+1 more Carolina Mora López
DOI: 10.1109/isscc49663.2026.11409263
Cited by: 1
References: 22

Abstract

We present a waveguide-based optogenetics neural probe with 1,280 electrodes, 384 recording channels, and 88 emission sites enabled by dual-layer silicon photonics. Thermo-optic switches are controlled by a custom photonic driver IC, while integrated tap couplers with photodiodes and a temperature sensor provide on-chip calibration and thermal monitoring. The probe achieves a large number of recording and emission sites, enabling reliable large-scale, cell-type-specific optogenetic studies.

Fields of Study & Subjects

Photoreceptor and optogenetics research Neuroscience and Neural Engineering Mechanical and Optical Resonators

Publication details

Journal / source
2026 IEEE International Solid-State Circuits Conference (ISSCC)
Publisher
IEEE
Pages
616–618
Publication date
15 February 2026