A Poct System Based on Solution-Gated Graphene Transistors for Highly-Sensitive and Rapid Detection of Exosomal Mirna

This study reported a portable point-of-care testing (POCT) system based on a solution-gated graphene transistor (SGGT) for highly sensitive detection of tumorderived exosomal miRNAs. The system demonstrated excellent portability, operational simplicity, and high detection sensitivity, achieving a limit of detection as low as$10^{-20} \mathrm{M}$. It also exhibited remarkable specificity, and each measurement only took approximately 400 seconds. The detection results for exosomal miRNA samples were consistent with those obtained by the gold standard qRTPCR method. With high visualization capability, userfriendly portability, and superior sensitivity, the system provided a novel strategy for tumor diagnosis.