Counterfactual Modeling With Fine-Tuned LLMs for Health Intervention Design and Sensor Data Augmentation

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Authors: Shovito Barua Soumma, Asiful Arefeen, S. Carpenter, Melanie Hingle, Hassan Ghasemzadeh
Cited by: 1
References: 20

Abstract

Counterfactual explanations (CFEs) provide human-centric interpretability by identifying the minimal, actionable changes required to alter a machine learning model's prediction. Therefore, CFs can be used as (i) interventions for abnormality prevention and (ii) augmented data for training robust models. we conduct a comprehensive evaluation of CF generation using large language models (LLMs), including GPT-4 (zero-shot and few-shot) and two open-source models-BioMistral-7B and LLaMA-3.1-8B-in both pretrained and fine-tuned configurations. Using the multimodal AI-READI clinical dataset, we assess CFs across three dimensions: intervention quality, feature diversity, and augmentation effectiveness. Fine-tuned LLMs, particularly LLaMA-3.1-8B, produce CFs with high plausibility (up to 99%), strong validity (up to 0.99), and realistic, behaviorally modifiable feature adjustments. When used for data augmentation under controlled label-scarcity settings, LLM-generated CFs substantially restore classifier performance, yielding an average 20% F1 recovery across three scarcity scenarios. Compared with optimization-based baselines such as DiCE, CFNOW, and NICE, LLMs offer a flexible, model-agnostic approach that generates more clinically plausible, behaviorally actionable and semantically coherent counterfactuals. Overall, this work demonstrates the promise of LLM-driven counterfactuals for both interpretable intervention design and data-efficient model training in sensor-based digital health.

Fields of Study & Subjects

Healthcare Technology and Patient Monitoring Context-Aware Activity Recognition Systems Model Reduction and Neural Networks

Publication details

Journal / source
IEEE Open Journal of Engineering in Medicine and Biology
Publisher
Institute of Electrical and Electronics Engineers (IEEE)
Volume
7
Pages
232–240
Publication date
1 January 2026
Language
EN