Prime Factorization Using Partially Constrained Multiple Quantum Annealing With Analytical and Pattern-Based Variable Reduction

Factorization of large semiprimes remains one of the most challenging problems for classical computers. Shor’s algorithm offers a quantum approach that reduces computational complexity, but its practical application is currently limited by hardware constraints. Meanwhile, as a provisional approach, quantum annealing (QA) has been explored through formulations of the quadratic unconstrained binary optimization (QUBO) problem. Among existing methods, the blockwise partial-product approach effectively reduced the QUBO variable count but was limited to semiprimes up to 21 bits. To extend factorization to larger semiprimes, this paper addresses key engineering challenges in constructing efficient QUBO formulations for prime factorization. We propose five techniques to reduce variable counts and improve scalability with current QA hardware: (1) dividing the problem into subproblems with partial constraints; (2) applying analytical reductions near the LSB; (3) applying analytical reductions near the MSB; (4) exploiting special patterns in semiprimes, with odd bit widths and long MSB-side zero sequences; and (5) balancing variable usage across both sides of the subproblem. Integrated into a QUBO converter, these methods enable stable factorization of semiprimes up to 47-bits within 20 seconds and can extend to special 2049-bit instances with 1001 consecutive MSB-side zeros.